Piecing together the puzzle of cutaneous mosaicism.

YuMi, Come and Play with Me! A Collaborative Robot for Piecing Together a Tangram Puzzle

Gene Regulation: Piecing Together the Puzzle of Enhancer Evolution

The sequences of some gene regulatory elements diverge considerably, even between closely related species. A detailed analysis of the fast-evolving sparkling enhancer in Drosophila now identifies key compensatory mechanisms and 'grammar' elements that are critical for maintaining functional integrity.

Piecing Together the Extracellular Puzzle

Large-scale screens to identify protein interactions typically underperform with eukaryotic extracellular proteins. In this issue, Özkan et al. report development of a high-throughput assay designed specifically for extracellular proteins that uncovers a wealth of new interactions among three protein superfamilies in Drosophila and sets the stage for more extensive screens.

Jigsaw percolation: What social networks can collaboratively solve a puzzle?

We introduce a new kind of percolation on finite graphs called jigsaw percolation. This model attempts to capture networks of people who innovate by merging ideas and who solve problems by piecing together solutions. Each person in a social network has a unique piece of a jigsaw puzzle. Acquainted people with compatible puzzle pieces merge their puzzle pieces. More generally, groups of people w...

The Puzzle of the Skin Patterns

Background: The pattern of distribution of skin diseases remains one of the most elusive problems in dermatology, particularly when multiple pathologies are involved and coexistence of patterns is present. Most skin diseases show a predilection for certain body areas and are located in characteristic patterns. Many dermatoses exhibit lesions in a segmental fashion concomitantly with disseminate...